As interest in the healing potential of psychedelics resurges in the West, so too emerge a series of questions about the medicalized frameworks within which psychedelic work is potentiated. The patriarchal paradigm that is the foundation of the medical-industrial complex, while widely accepted, comes with a series of reality constructs that perpetuate great harm via systemic oppression, the dismemberment of matter and spirit, and the desecration of the natural world. Psychedelics have the potential to disrupt the beliefs that underpin these issues. This revelatory quality, though, can be dangerous: the rending of our fundamental assumptions about the real can send us into profoundly challenging states of consciousness. Yet this power also contains great possibility: in making visible the patriarchal illusions that underscore what we consider “the real”, psychedelics can serve us in the unwinding of internalized oppression.  But, then what? If reality is not what patriarchy says it is, what is it? What paradigms support and give rise to individual and collective liberation? Nondual orientations are one such framework, holding that all of life is fundamentally interconnected. By considering “the real” through a nondual lens, the mythopoetic possibilities of reality are integrated through a somatic ground. Nonduality illuminates the necessity of cultivating cognitive liberty as a practice of activism and creativity as a gateway to freedom. Where: PhilaDelic – Conference on the Transdisciplinary Frontier